The protein encoded by this gene is a type II membrane protein that is thought to catalyze the transfer of sialic acid from CMP-sialic acid to N-linked oligosaccharides and glycoproteins. The encoded protein may be found in the Golgi apparatus and may be involved in the production of polysialic acid, a modulator of the adhesive properties of neural cell adhesion molecule (NCAM1). This protein is a member of glycosyltransferase family 29. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for ST8SIA2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ST8SIA2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ST8SIA2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr15:92,123,884–92,124,686 | 269.6 kb | Distal (>10kb) Multiome | 171 | |
| chr15:92,266,540–92,267,320 | 127.1 kb | Distal (>10kb) Multiome | 101 | |
| chr15:92,268,620–92,269,277 | 124.9 kb | Distal (>10kb) Multiome | 129 | |
| chr15:92,343,759–92,344,647 | 49.6 kb | Distal (>10kb) Multiome | 59 | |
| chr15:92,391,739–92,391,932 | 1.9 kb | Proximal (<10kb) | 83 | |
| chr15:92,392,382–92,392,797 | 1.1 kb | Proximal (<10kb) | 59 | |
| chr15:92,393,091–92,395,383 | 16 bp | At TSS Multiome | 343 | |
| chr15:92,634,312–92,635,219 | 240.9 kb | Distal (>10kb) Multiome | 57 | |
| chr15:92,647,486–92,648,715 | 254.1 kb | Distal (>10kb) Multiome | 186 | |
| chr15:92,655,159–92,656,121 | 261.8 kb | Distal (>10kb) Multiome | 425 | |
| chr15:92,667,223–92,667,908 | 273.5 kb | Distal (>10kb) Multiome | 251 | |
| chr15:92,711,051–92,711,898 | 317.6 kb | Distal (>10kb) Multiome HiCAR | 157 | |
| chr15:92,714,124–92,715,096 | 320.9 kb | Distal (>10kb) Multiome HiCAR | 524 |
Genomic view of the ST8SIA2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.