SSTR2

somatostatin receptor 2

Somatostatin acts at many sites to inhibit the release of many hormones and other secretory proteins. The biologic effects of somatostatin are probably mediated by a family of G protein-coupled receptors that are expressed in a tissue-specific manner. SSTR2 is a member of the superfamily of receptors having seven transmembrane segments and is expressed in highest levels in cerebrum and kidney. [provided by RefSeq, Jul 2008]

Developmental clusters: GC6

Biological processes 23 terms

G protein-coupled receptor activity (GO:0004930)G protein-coupled receptor signaling pathway (GO:0007186)G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger (GO:0007187)G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger (GO:0007187)PDZ domain binding (GO:0030165)cellular response to estradiol stimulus (GO:0071392)cellular response to glucocorticoid stimulus (GO:0071385)cytoplasm (GO:0005737)cytosol (GO:0005829)membrane (GO:0016020)negative regulation of cell population proliferation (GO:0008285)negative regulation of cell population proliferation (GO:0008285)neuron projection (GO:0043005)neuropeptide binding (GO:0042923)neuropeptide signaling pathway (GO:0007218)plasma membrane (GO:0005886)plasma membrane (GO:0005886)plasma membrane (GO:0005886)protein binding (GO:0005515)somatostatin receptor activity (GO:0004994)somatostatin receptor activity (GO:0004994)somatostatin receptor activity (GO:0004994)somatostatin signaling pathway (GO:0038170)

Expression (TPM)

TFs regulating SSTR2 0 TFs

Transcription factors with Perturb-seq knockdown data for SSTR2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SSTR2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to SSTR2

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SSTR2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr17:72,556,835–72,557,428	607.9 kb	Distal (>10kb) Multiome HiCAR	400
chr17:73,092,145–73,093,083	72.3 kb	Distal (>10kb) Multiome	900
chr17:73,156,070–73,156,871	8.6 kb	Proximal (<10kb) Multiome	439
chr17:73,160,789–73,161,852	3.7 kb	Proximal (<10kb) Multiome	148
chr17:73,164,283–73,166,339	81 bp	At TSS Multiome	454
chr17:73,170,439–73,170,651	5.4 kb	Proximal (<10kb)	27
chr17:73,192,033–73,193,741	28.0 kb	Distal (>10kb) Multiome	877
chr17:73,231,620–73,233,239	67.4 kb	Distal (>10kb) Multiome	964
chr17:73,310,270–73,312,686	145.9 kb	Distal (>10kb) Multiome	1078
chr17:73,317,321–73,317,925	152.6 kb	Distal (>10kb) Multiome	153
chr17:73,318,653–73,319,222	154.0 kb	Distal (>10kb) Multiome	44
chr17:73,341,495–73,342,744	177.2 kb	Distal (>10kb) Multiome	347
chr17:73,342,845–73,343,860	178.5 kb	Distal (>10kb) Multiome	294
chr17:73,351,620–73,352,260	186.9 kb	Distal (>10kb) Multiome	17
chr17:73,359,891–73,361,657	196.2 kb	Distal (>10kb) Multiome	310
chr17:73,363,301–73,364,389	199.0 kb	Distal (>10kb) Multiome	140

Genome Browser

Genomic view of the SSTR2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.