The scavenger receptor cysteine-rich (SRCR) superfamily is an ancient and highly conserved group of cell surface and/or secreted proteins, some of which are involved in the development of the immune system and the regulation of both innate and adaptive immune responses. Group B SRCR domains usually contain 8 regularly spaced cysteines that give rise to a well-defined intradomain disulfide-bond pattern.[supplied by OMIM, Apr 2004]
Transcription factors with Perturb-seq knockdown data for SSC4D. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SSC4D upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SSC4D, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:76,163,449–76,164,544 | 229.5 kb | Distal (>10kb) Multiome | 132 | |
| chr7:76,166,338–76,167,166 | 226.8 kb | Distal (>10kb) Multiome | 644 | |
| chr7:76,177,965–76,178,641 | 215.2 kb | Distal (>10kb) Multiome | 670 | |
| chr7:76,201,356–76,202,307 | 191.7 kb | Distal (>10kb) Multiome | 937 | |
| chr7:76,234,695–76,235,681 | 158.2 kb | Distal (>10kb) Multiome | 329 | |
| chr7:76,259,707–76,261,052 | 133.1 kb | Distal (>10kb) Multiome | 332 | |
| chr7:76,267,044–76,267,853 | 126.1 kb | Distal (>10kb) Multiome | 211 | |
| chr7:76,282,299–76,283,220 | 110.8 kb | Distal (>10kb) Multiome | 237 | |
| chr7:76,291,428–76,292,275 | 101.6 kb | Distal (>10kb) Multiome | 767 | |
| chr7:76,302,207–76,304,173 | 91.0 kb | Distal (>10kb) Multiome | 943 | |
| chr7:76,314,028–76,314,686 | 79.1 kb | Distal (>10kb) Multiome | 715 | |
| chr7:76,317,523–76,319,173 | 75.3 kb | Distal (>10kb) Multiome | 840 | |
| chr7:76,358,237–76,359,989 | 34.2 kb | Distal (>10kb) Multiome | 1036 | |
| chr7:76,379,650–76,380,602 | 13.4 kb | Distal (>10kb) Multiome | 853 | |
| chr7:76,392,882–76,394,121 | 197 bp | At TSS Multiome HiCAR | 932 | |
| chr7:76,395,928–76,396,741 | 2.7 kb | Proximal (<10kb) Multiome HiCAR | 152 | |
| chr7:76,397,187–76,397,970 | 4.1 kb | Proximal (<10kb) Multiome HiCAR | 496 | |
| chr7:76,409,261–76,409,956 | 16.3 kb | Distal (>10kb) Multiome HiCAR | 281 | |
| chr7:76,510,075–76,510,721 | 116.9 kb | Distal (>10kb) Multiome | 201 | |
| chr7:76,548,975–76,549,826 | 155.8 kb | Distal (>10kb) Multiome | 505 |
Genomic view of the SSC4D locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.