Enables RNA binding activity. Involved in protein targeting to ER. Located in nucleus. Part of signal recognition particle, endoplasmic reticulum targeting. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for SRP14. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SRP14 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SRP14, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr15:39,782,369–39,782,987 | 256.5 kb | Distal (>10kb) Multiome | 737 | |
| chr15:39,844,965–39,845,763 | 193.7 kb | Distal (>10kb) Multiome | 26 | |
| chr15:39,888,792–39,889,226 | 150.2 kb | Distal (>10kb) Multiome | 62 | |
| chr15:39,920,609–39,921,284 | 118.2 kb | Distal (>10kb) Multiome | 707 | |
| chr15:39,933,904–39,934,437 | 105.0 kb | Distal (>10kb) Multiome | 698 | |
| chr15:40,038,862–40,039,388 | 23 bp | At TSS Multiome | 750 | |
| chr15:40,045,160–40,045,385 | 6.0 kb | Proximal (<10kb) | 488 | |
| chr15:40,108,639–40,109,491 | 69.9 kb | Distal (>10kb) Multiome | 798 | |
| chr15:40,160,791–40,161,326 | 121.8 kb | Distal (>10kb) Multiome | 762 | |
| chr15:40,323,099–40,324,127 | 284.3 kb | Distal (>10kb) Multiome | 737 |
Genomic view of the SRP14 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.