SRCAP
Snf2 related CREBBP activator protein | DOMO1, KIAA0309, SWR1

This gene encodes the core catalytic component of the multiprotein chromatin-remodeling SRCAP complex. The encoded protein is an ATPase that is necessary for the incorporation of the histone variant H2A.Z into nucleosomes. It can function as a transcriptional activator in Notch-mediated, CREB-mediated and steroid receptor-mediated transcription. Mutations in this gene cause Floating-Harbor syndrome, a rare disorder characterized by short stature, language deficits and dysmorphic facial features. [provided by RefSeq, Feb 2012]

Member of: DE-2 DE-2.3
Biological processes 27 terms
ATP binding (GO:0005524)ATP hydrolysis activity (GO:0016887)ATP hydrolysis activity (GO:0016887)ATP-dependent chromatin remodeler activity (GO:0140658)ATP-dependent chromatin remodeler activity (GO:0140658)ATP-dependent chromatin remodeler activity (GO:0140658)DNA binding (GO:0003677)Swr1 complex (GO:0000812)Swr1 complex (GO:0000812)cAMP/PKA signal transduction (GO:0141156)catalytic complex (GO:1902494)chromatin (GO:0000785)chromatin remodeling (GO:0006338)chromatin remodeling (GO:0006338)histone binding (GO:0042393)nuclear body (GO:0016604)nucleoplasm (GO:0005654)nucleus (GO:0005634)nucleus (GO:0005634)nucleus (GO:0005634)perinuclear region of cytoplasm (GO:0048471)positive regulation of transcription by RNA polymerase II (GO:0045944)protein binding (GO:0005515)protein-containing complex (GO:0032991)regulation of DNA-templated transcription (GO:0006355)regulation of gene expression (GO:0010468)transcription coactivator activity (GO:0003713)
Expression (TPM)
SRCAP — as a Regulated Gene

TFs regulating SRCAP 0 TFs

Transcription factors with Perturb-seq knockdown data for SRCAP. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SRCAP upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

Data: Effect:
TF Mean coef Binding Outlier TF→Gene link

Elements linked to SRCAP

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SRCAP, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility Element Dist. to TSS Link type TFs
chr16:30,400,026–30,401,048 297.7 kb Distal (>10kb) Multiome 839
chr16:30,406,974–30,408,429 290.7 kb Distal (>10kb) Multiome 908
chr16:30,417,414–30,418,576 280.1 kb Distal (>10kb) Multiome 543
chr16:30,429,571–30,430,773 268.0 kb Distal (>10kb) Multiome 1060
chr16:30,445,340–30,446,062 252.4 kb Distal (>10kb) Multiome 898
chr16:30,526,068–30,527,896 170.8 kb Distal (>10kb) Multiome 1004
chr16:30,534,370–30,535,460 163.3 kb Distal (>10kb) Multiome 957
chr16:30,557,913–30,558,847 139.7 kb Distal (>10kb) Multiome 1025
chr16:30,571,001–30,572,505 126.2 kb Distal (>10kb) Multiome 950
chr16:30,585,243–30,586,223 112.4 kb Distal (>10kb) Multiome 588
chr16:30,609,586–30,610,748 87.8 kb Distal (>10kb) Multiome 1030
chr16:30,634,070–30,634,986 63.8 kb Distal (>10kb) Multiome 907
chr16:30,650,029–30,651,831 47.5 kb Distal (>10kb) Multiome 992
chr16:30,657,638–30,659,894 39.9 kb Distal (>10kb) Multiome 1053
chr16:30,677,814–30,678,622 20.0 kb Distal (>10kb) Multiome 177
chr16:30,693,876–30,694,185 4.0 kb Proximal (<10kb) 239
chr16:30,697,755–30,699,614 910 bp At TSS Multiome 1153
chr16:30,747,864–30,748,943 50.1 kb Distal (>10kb) Multiome 824
chr16:30,761,380–30,762,606 64.0 kb Distal (>10kb) Multiome 885
chr16:30,774,965–30,776,186 77.3 kb Distal (>10kb) Multiome 1025
chr16:30,786,385–30,788,019 89.0 kb Distal (>10kb) Multiome 885
chr16:30,805,468–30,806,187 107.5 kb Distal (>10kb) Multiome 969
chr16:30,814,045–30,814,733 116.3 kb Distal (>10kb) Multiome 995
chr16:30,841,062–30,841,882 143.4 kb Distal (>10kb) Multiome 49
chr16:30,874,866–30,875,643 177.1 kb Distal (>10kb) Multiome 1108
chr16:30,893,485–30,894,587 196.0 kb Distal (>10kb) Multiome 950
chr16:30,895,854–30,897,426 198.9 kb Distal (>10kb) Multiome 822
chr16:30,901,969–30,902,794 204.1 kb Distal (>10kb) Multiome 579
chr16:30,921,611–30,925,097 225.2 kb Distal (>10kb) Multiome 1132
chr16:30,927,705–30,928,596 230.0 kb Distal (>10kb) Multiome 274
chr16:30,941,803–30,942,254 243.9 kb Distal (>10kb) Multiome 507
chr16:30,947,471–30,950,635 252.0 kb Distal (>10kb) Multiome 1066
chr16:30,953,370–30,954,135 255.6 kb Distal (>10kb) Multiome 499
chr16:30,956,960–30,958,498 259.5 kb Distal (>10kb) Multiome 1022
chr16:30,984,837–30,985,709 287.0 kb Distal (>10kb) Multiome 787
chr16:30,996,877–30,998,001 299.2 kb Distal (>10kb) Multiome 759

Genome Browser

Genomic view of the SRCAP locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.

chr16:30,390,026 – 31,008,001
Proximal 1 kb Distal 10 kb Multiome HiCAR ATAC-seq RNA-seq
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