The protein encoded by this gene belongs to the cytospin-A family. It is localized in the nucleus, and highly expressed in testis and some cancer cell lines. A chromosomal translocation involving this gene and platelet-derived growth factor receptor, beta gene (PDGFRB) may be a cause of juvenile myelomonocytic leukemia. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011]
Transcription factors with Perturb-seq knockdown data for SPECC1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SPECC1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SPECC1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:19,744,539–19,745,417 | 264.3 kb | Distal (>10kb) Multiome | 325 | |
| chr17:19,866,833–19,868,282 | 141.5 kb | Distal (>10kb) Multiome | 560 | |
| chr17:19,977,322–19,978,428 | 31.5 kb | Distal (>10kb) Multiome | 1017 | |
| chr17:19,992,824–19,993,272 | 16.3 kb | Distal (>10kb) Multiome | 455 | |
| chr17:20,008,666–20,010,100 | 14 bp | At TSS Multiome | 646 | |
| chr17:20,155,600–20,156,828 | 146.7 kb | Distal (>10kb) Multiome | 631 |
Genomic view of the SPECC1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.