Predicted to enable ribosome binding activity. Involved in signal peptide processing; viral protein processing; and virion assembly. Located in endoplasmic reticulum membrane. Part of signal peptidase complex. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for SPCS1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SPCS1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SPCS1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:52,409,430–52,411,187 | 295.8 kb | Distal (>10kb) Multiome | 813 | |
| chr3:52,444,941–52,445,411 | 261.0 kb | Distal (>10kb) Multiome | 426 | |
| chr3:52,455,213–52,455,878 | 250.6 kb | Distal (>10kb) Multiome | 630 | |
| chr3:52,518,607–52,519,389 | 187.1 kb | Distal (>10kb) Multiome | 176 | |
| chr3:52,533,486–52,535,316 | 172.2 kb | Distal (>10kb) Multiome | 648 | |
| chr3:52,536,232–52,537,450 | 169.6 kb | Distal (>10kb) Multiome | 901 | |
| chr3:52,685,427–52,686,463 | 20.3 kb | Distal (>10kb) Multiome | 933 | |
| chr3:52,705,495–52,706,415 | 129 bp | At TSS Multiome | 862 | |
| chr3:52,714,354–52,715,301 | 8.6 kb | Proximal (<10kb) Multiome | 224 | |
| chr3:52,770,467–52,771,332 | 64.8 kb | Distal (>10kb) Multiome | 788 | |
| chr3:52,897,094–52,897,995 | 191.5 kb | Distal (>10kb) Multiome | 474 |
Genomic view of the SPCS1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.