Predicted to enable microtubule binding activity. Predicted to be involved in regulation of cytoskeleton organization. Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for SPATA4. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SPATA4 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SPATA4, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:176,186,135–176,186,515 | 9.1 kb | Proximal (<10kb) | 65 | |
| chr4:176,193,322–176,193,538 | 2.0 kb | Proximal (<10kb) | 55 | |
| chr4:176,193,664–176,194,119 | 1.5 kb | Proximal (<10kb) | 115 | |
| chr4:176,194,750–176,196,011 | at TSS | At TSS | 672 | |
| chr4:176,198,590–176,198,794 | 3.0 kb | Proximal (<10kb) | 18 |
Genomic view of the SPATA4 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.