This gene encodes an SH3 domain-containing adaptor protein. The presence of SH3 domains play a role in this protein's ability to bind other cytoplasmic molecules and contribute to cystoskeletal organization, cell adhesion and migration, signaling, and gene expression. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
Transcription factors with Perturb-seq knockdown data for SORBS3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SORBS3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SORBS3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:22,244,388–22,245,751 | 306.8 kb | Distal (>10kb) Multiome HiCAR | 1013 | |
| chr8:22,275,120–22,276,011 | 276.6 kb | Distal (>10kb) Multiome | 195 | |
| chr8:22,365,087–22,366,071 | 186.3 kb | Distal (>10kb) Multiome | 444 | |
| chr8:22,366,837–22,368,383 | 184.6 kb | Distal (>10kb) Multiome | 859 | |
| chr8:22,440,466–22,441,769 | 110.8 kb | Distal (>10kb) Multiome HiCAR | 784 | |
| chr8:22,548,856–22,550,046 | 2.4 kb | Proximal (<10kb) Multiome | 539 | |
| chr8:22,551,208–22,552,929 | 357 bp | At TSS Multiome | 406 | |
| chr8:22,561,173–22,562,479 | 9.9 kb | Proximal (<10kb) Multiome | 678 | |
| chr8:22,565,061–22,566,429 | 13.8 kb | Distal (>10kb) Multiome | 404 | |
| chr8:22,574,221–22,574,708 | 22.6 kb | Distal (>10kb) Multiome | 527 | |
| chr8:22,578,724–22,579,696 | 27.2 kb | Distal (>10kb) Multiome | 404 | |
| chr8:22,588,723–22,589,902 | 37.3 kb | Distal (>10kb) Multiome | 612 | |
| chr8:22,594,681–22,595,713 | 43.4 kb | Distal (>10kb) Multiome | 402 | |
| chr8:22,597,003–22,600,290 | 45.5 kb | Distal (>10kb) Multiome | 889 | |
| chr8:22,604,300–22,605,436 | 52.8 kb | Distal (>10kb) Multiome | 1053 | |
| chr8:22,622,764–22,623,329 | 71.1 kb | Distal (>10kb) Multiome | 431 | |
| chr8:22,658,639–22,659,248 | 107.0 kb | Distal (>10kb) Multiome | 290 | |
| chr8:22,668,686–22,669,459 | 117.2 kb | Distal (>10kb) Multiome | 637 | |
| chr8:22,691,357–22,691,921 | 139.7 kb | Distal (>10kb) Multiome | 153 | |
| chr8:22,692,857–22,693,984 | 141.6 kb | Distal (>10kb) Multiome | 490 | |
| chr8:22,694,125–22,696,129 | 143.6 kb | Distal (>10kb) Multiome | 662 | |
| chr8:22,864,299–22,865,847 | 313.1 kb | Distal (>10kb) Multiome | 507 |
Genomic view of the SORBS3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.