Transcription factors with Perturb-seq knockdown data for SNHG26. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SNHG26 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SNHG26, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:22,549,622–22,550,567 | 304.0 kb | Distal (>10kb) Multiome HiCAR | 336 | |
| chr7:22,703,088–22,703,942 | 150.7 kb | Distal (>10kb) Multiome | 251 | |
| chr7:22,708,694–22,710,118 | 144.9 kb | Distal (>10kb) Multiome | 287 | |
| chr7:22,782,701–22,783,430 | 71.2 kb | Distal (>10kb) Multiome | 163 | |
| chr7:22,822,496–22,823,057 | 31.4 kb | Distal (>10kb) Multiome | 671 | |
| chr7:22,853,488–22,855,243 | 19 bp | At TSS Multiome | 941 | |
| chr7:22,864,935–22,865,537 | 8.8 kb | Proximal (<10kb) | 114 | |
| chr7:22,937,587–22,938,683 | 84.0 kb | Distal (>10kb) Multiome | 139 | |
| chr7:23,013,184–23,014,464 | 160.0 kb | Distal (>10kb) Multiome | 751 | |
| chr7:23,105,409–23,106,715 | 251.5 kb | Distal (>10kb) Multiome | 833 | |
| chr7:23,116,020–23,116,472 | 261.9 kb | Distal (>10kb) Multiome | 105 |
Genomic view of the SNHG26 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.