Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for SMIM29. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SMIM29 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SMIM29, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:34,056,249–34,056,753 | 192.6 kb | Distal (>10kb) Multiome | 192 | |
| chr6:34,143,812–34,144,483 | 104.9 kb | Distal (>10kb) Multiome | 304 | |
| chr6:34,144,948–34,146,170 | 103.3 kb | Distal (>10kb) Multiome | 310 | |
| chr6:34,196,308–34,196,855 | 52.5 kb | Distal (>10kb) Multiome HiCAR | 723 | |
| chr6:34,202,245–34,203,164 | 46.2 kb | Distal (>10kb) Multiome | 90 | |
| chr6:34,223,440–34,224,542 | 25.0 kb | Distal (>10kb) Multiome | 795 | |
| chr6:34,234,536–34,237,980 | 13.6 kb | Distal (>10kb) Multiome | 1100 | |
| chr6:34,246,464–34,249,721 | 2.3 kb | Proximal (<10kb) Multiome | 1030 | |
| chr6:34,391,718–34,393,315 | 143.7 kb | Distal (>10kb) Multiome HiCAR | 1033 | |
| chr6:34,425,555–34,426,314 | 177.1 kb | Distal (>10kb) Multiome HiCAR | 859 | |
| chr6:34,465,686–34,466,203 | 217.0 kb | Distal (>10kb) Multiome | 319 | |
| chr6:34,527,078–34,527,644 | 278.3 kb | Distal (>10kb) Multiome | 606 | |
| chr6:34,531,348–34,532,578 | 283.0 kb | Distal (>10kb) Multiome | 150 |
Genomic view of the SMIM29 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.