Involved in mitochondrial cytochrome c oxidase assembly. Located in mitochondrial inner membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for SMIM20. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SMIM20 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SMIM20, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:25,654,656–25,656,013 | 258.9 kb | Distal (>10kb) Multiome | 352 | |
| chr4:25,862,025–25,864,342 | 51.2 kb | Distal (>10kb) Multiome | 505 | |
| chr4:25,890,607–25,891,102 | 23.5 kb | Distal (>10kb) Multiome | 58 | |
| chr4:25,913,305–25,914,731 | 164 bp | At TSS Multiome | 955 | |
| chr4:25,993,098–25,994,248 | 79.5 kb | Distal (>10kb) Multiome | 370 | |
| chr4:26,028,604–26,030,844 | 114.6 kb | Distal (>10kb) Multiome | 374 |
Genomic view of the SMIM20 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.