Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for SMCO4. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SMCO4 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SMCO4, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:93,330,006–93,331,029 | 212.8 kb | Distal (>10kb) Multiome | 319 | |
| chr11:93,444,389–93,445,160 | 98.6 kb | Distal (>10kb) Multiome | 173 | |
| chr11:93,542,187–93,543,870 | 4 bp | At TSS Multiome | 790 | |
| chr11:93,624,139–93,625,031 | 81.2 kb | Distal (>10kb) Multiome | 122 | |
| chr11:93,661,372–93,662,246 | 118.3 kb | Distal (>10kb) Multiome | 1008 | |
| chr11:93,740,823–93,742,225 | 198.2 kb | Distal (>10kb) Multiome | 900 | |
| chr11:93,765,352–93,766,055 | 222.4 kb | Distal (>10kb) Multiome | 124 | |
| chr11:93,770,077–93,770,855 | 227.1 kb | Distal (>10kb) Multiome | 100 | |
| chr11:93,783,874–93,784,997 | 240.9 kb | Distal (>10kb) Multiome | 860 |
Genomic view of the SMCO4 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.