Enables DNA secondary structure binding activity and ubiquitin protein ligase binding activity. Involved in several processes, including cellular senescence; negative regulation by host of viral genome replication; and telomere maintenance via recombination. Located in chromosome and nuclear body. Part of Smc5-Smc6 complex. Is active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for SMC6. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SMC6 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SMC6, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:17,517,918–17,518,924 | 235.4 kb | Distal (>10kb) Multiome | 501 | |
| chr2:17,538,445–17,541,363 | 213.2 kb | Distal (>10kb) Multiome | 1001 | |
| chr2:17,719,690–17,719,837 | 4.8 kb | Proximal (<10kb) | 63 | |
| chr2:17,719,950–17,720,071 | 5.1 kb | Proximal (<10kb) | 19 | |
| chr2:17,747,989–17,748,437 | 5.4 kb | Proximal (<10kb) | 60 | |
| chr2:17,752,946–17,754,742 | 83 bp | At TSS Multiome | 969 | |
| chr2:17,830,142–17,831,178 | 76.9 kb | Distal (>10kb) Multiome | 569 | |
| chr2:17,877,566–17,880,371 | 124.7 kb | Distal (>10kb) Multiome | 654 | |
| chr2:17,892,519–17,893,824 | 139.2 kb | Distal (>10kb) Multiome | 234 | |
| chr2:17,974,313–17,976,066 | 221.6 kb | Distal (>10kb) Multiome | 128 | |
| chr2:18,049,307–18,049,991 | 295.8 kb | Distal (>10kb) Multiome | 63 |
Genomic view of the SMC6 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.