This gene encodes a component of a conserved striatin-interacting phosphatase and kinase complex. Striatin family complexes participate in a variety of cellular processes including signaling, cell cycle control, cell migration, Golgi assembly, and apoptosis. The protein encoded by this gene is a coiled-coil, tail-anchored membrane protein with a single C-terminal transmembrane domain that is posttranslationally inserted into membranes. Mutations in this gene are associated with Brugada syndrome, a cardiac channelopathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015]
Transcription factors with Perturb-seq knockdown data for SLMAP. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SLMAP upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SLMAP, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:57,596,484–57,598,208 | 267.1 kb | Distal (>10kb) Multiome | 936 | |
| chr3:57,692,365–57,693,415 | 171.7 kb | Distal (>10kb) Multiome | 923 | |
| chr3:57,727,873–57,728,338 | 136.5 kb | Distal (>10kb) Multiome | 20 | |
| chr3:57,755,657–57,757,330 | 108.4 kb | Distal (>10kb) Multiome | 930 | |
| chr3:57,969,842–57,970,308 | 105.5 kb | Distal (>10kb) Multiome | 332 | |
| chr3:57,992,220–57,993,259 | 128.1 kb | Distal (>10kb) Multiome | 382 | |
| chr3:57,998,619–57,999,287 | 134.3 kb | Distal (>10kb) Multiome | 336 | |
| chr3:58,002,992–58,003,441 | 138.6 kb | Distal (>10kb) Multiome | 128 | |
| chr3:58,006,378–58,007,041 | 142.2 kb | Distal (>10kb) Multiome | 155 | |
| chr3:58,007,913–58,009,633 | 143.8 kb | Distal (>10kb) Multiome | 747 | |
| chr3:58,021,094–58,022,164 | 157.0 kb | Distal (>10kb) Multiome | 478 | |
| chr3:58,034,682–58,035,269 | 170.4 kb | Distal (>10kb) Multiome | 260 | |
| chr3:58,049,229–58,049,752 | 184.8 kb | Distal (>10kb) Multiome | 668 |
Genomic view of the SLMAP locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.