This gene encodes a sodium/proton exchanger that is a member of the solute carrier 9 protein family. The encoded protein localizes the to the late recycling endosomes and may play an important role in maintaining cation homeostasis. Mutations in this gene are associated with autism susceptibility 16 and attention-deficit/hyperactivity disorder. [provided by RefSeq, Mar 2012]
Transcription factors with Perturb-seq knockdown data for SLC9A9. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SLC9A9 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SLC9A9, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:143,805,063–143,806,295 | 42.8 kb | Distal (>10kb) Multiome | 164 | |
| chr3:143,839,907–143,840,281 | 8.2 kb | Proximal (<10kb) | 41 | |
| chr3:143,846,931–143,847,349 | 1.1 kb | Proximal (<10kb) | 10 | |
| chr3:143,847,763–143,848,060 | 424 bp | At TSS | 152 | |
| chr3:143,848,219–143,848,571 | at TSS | At TSS | 161 | |
| chr3:143,970,615–143,973,789 | 123.3 kb | Distal (>10kb) Multiome | 1038 |
Genomic view of the SLC9A9 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.