Predicted to be involved in developmental process. Predicted to act upstream of or within hematopoietic progenitor cell differentiation. Predicted to be located in cytoplasm and nucleus. Implicated in progressive myoclonus epilepsy. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for SLC7A6OS. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SLC7A6OS upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SLC7A6OS, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr16:68,019,222–68,020,043 | 291.5 kb | Distal (>10kb) Multiome | 108 | |
| chr16:68,022,490–68,023,556 | 287.7 kb | Distal (>10kb) Multiome | 958 | |
| chr16:68,084,205–68,086,133 | 225.7 kb | Distal (>10kb) Multiome | 1092 | |
| chr16:68,235,016–68,238,254 | 74.8 kb | Distal (>10kb) Multiome | 1055 | |
| chr16:68,239,582–68,240,355 | 70.9 kb | Distal (>10kb) Multiome | 223 | |
| chr16:68,244,730–68,245,757 | 65.7 kb | Distal (>10kb) Multiome | 803 | |
| chr16:68,264,033–68,265,087 | 46.5 kb | Distal (>10kb) Multiome HiCAR | 876 | |
| chr16:68,310,451–68,311,505 | 72 bp | At TSS Multiome | 1061 | |
| chr16:68,328,654–68,329,423 | 17.8 kb | Distal (>10kb) Multiome | 438 | |
| chr16:68,420,400–68,420,906 | 109.6 kb | Distal (>10kb) Multiome | 58 | |
| chr16:68,447,981–68,449,250 | 137.7 kb | Distal (>10kb) Multiome | 795 | |
| chr16:68,520,489–68,521,019 | 209.8 kb | Distal (>10kb) Multiome | 602 | |
| chr16:68,528,418–68,529,128 | 217.8 kb | Distal (>10kb) Multiome | 552 | |
| chr16:68,529,733–68,530,671 | 219.2 kb | Distal (>10kb) Multiome | 831 | |
| chr16:68,538,873–68,540,027 | 228.3 kb | Distal (>10kb) Multiome | 764 |
Genomic view of the SLC7A6OS locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.