Transcription factors with Perturb-seq knockdown data for SLC7A14-AS1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SLC7A14-AS1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SLC7A14-AS1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:170,180,833–170,182,100 | 285.5 kb | Distal (>10kb) Multiome | 813 | |
| chr3:170,221,926–170,223,285 | 244.9 kb | Distal (>10kb) Multiome | 847 | |
| chr3:170,356,326–170,358,653 | 110.0 kb | Distal (>10kb) Multiome | 971 | |
| chr3:170,418,375–170,421,188 | 48.5 kb | Distal (>10kb) Multiome | 413 | |
| chr3:170,425,589–170,426,593 | 41.1 kb | Distal (>10kb) Multiome | 432 | |
| chr3:170,476,158–170,477,136 | 9.4 kb | Proximal (<10kb) Multiome | 116 | |
| chr3:170,584,438–170,585,040 | 117.5 kb | Distal (>10kb) Multiome | 442 | |
| chr3:170,685,663–170,686,879 | 218.8 kb | Distal (>10kb) Multiome HiCAR | 9 | |
| chr3:170,697,673–170,698,830 | 231.0 kb | Distal (>10kb) Multiome | 176 | |
| chr3:170,817,407–170,818,229 | 350.5 kb | Distal (>10kb) Multiome HiCAR | 68 |
Genomic view of the SLC7A14-AS1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.