Transport of small hydrophilic substances across cell membranes is mediated by substrate-specific transporter proteins which have been classified into several families of related genes. The protein encoded by this gene belongs to the sodium:neurotransmitter symporter (SNF) family and functions as a proline transporter expressed in kidney and small intestine. Mutations in this gene are associated with Hyperglycinuria and Iminoglycinuria. [provided by RefSeq, Jul 2020]
Transcription factors with Perturb-seq knockdown data for SLC6A20. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SLC6A20 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SLC6A20, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:45,593,037–45,594,632 | 203.1 kb | Distal (>10kb) Multiome | 938 | |
| chr3:45,673,142–45,673,693 | 123.1 kb | Distal (>10kb) Multiome | 31 | |
| chr3:45,684,209–45,684,875 | 111.9 kb | Distal (>10kb) Multiome | 109 | |
| chr3:45,685,643–45,686,405 | 110.4 kb | Distal (>10kb) Multiome | 42 | |
| chr3:45,688,221–45,689,801 | 107.3 kb | Distal (>10kb) Multiome | 1010 | |
| chr3:45,756,823–45,757,497 | 39.1 kb | Distal (>10kb) Multiome | 7 | |
| chr3:45,760,846–45,761,421 | 35.3 kb | Distal (>10kb) Multiome | 280 | |
| chr3:45,796,192–45,796,864 | 18 bp | At TSS Multiome | 188 | |
| chr3:45,841,672–45,842,368 | 45.7 kb | Distal (>10kb) Multiome | 746 | |
| chr3:45,995,063–45,996,144 | 199.3 kb | Distal (>10kb) Multiome | 790 |
Genomic view of the SLC6A20 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.