SLC6A16 shows structural characteristics of an Na(+)- and Cl(-)-dependent neurotransmitter transporter, including 12 transmembrane (TM) domains, intracellular N and C termini, and large extracellular loops containing multiple N-glycosylation sites.[supplied by OMIM, Mar 2008]
Transcription factors with Perturb-seq knockdown data for SLC6A16. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SLC6A16 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SLC6A16, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:49,017,642–49,018,292 | 291.0 kb | Distal (>10kb) Multiome | 480 | |
| chr19:49,019,277–49,019,889 | 289.4 kb | Distal (>10kb) Multiome | 233 | |
| chr19:49,055,975–49,056,714 | 252.7 kb | Distal (>10kb) Multiome | 431 | |
| chr19:49,064,668–49,065,682 | 243.8 kb | Distal (>10kb) Multiome | 226 | |
| chr19:49,071,761–49,072,903 | 236.9 kb | Distal (>10kb) Multiome | 278 | |
| chr19:49,084,646–49,086,115 | 223.6 kb | Distal (>10kb) Multiome | 1030 | |
| chr19:49,113,727–49,115,240 | 193.9 kb | Distal (>10kb) Multiome | 746 | |
| chr19:49,118,477–49,120,300 | 189.8 kb | Distal (>10kb) Multiome | 949 | |
| chr19:49,127,647–49,128,949 | 180.8 kb | Distal (>10kb) Multiome | 1000 | |
| chr19:49,132,975–49,134,197 | 175.4 kb | Distal (>10kb) Multiome | 179 | |
| chr19:49,142,781–49,143,252 | 165.9 kb | Distal (>10kb) Multiome | 299 | |
| chr19:49,145,727–49,146,720 | 162.7 kb | Distal (>10kb) Multiome | 511 | |
| chr19:49,148,659–49,150,947 | 158.4 kb | Distal (>10kb) Multiome | 917 | |
| chr19:49,151,539–49,152,548 | 157.0 kb | Distal (>10kb) Multiome | 497 | |
| chr19:49,157,555–49,158,336 | 151.2 kb | Distal (>10kb) Multiome | 599 | |
| chr19:49,210,032–49,211,225 | 98.4 kb | Distal (>10kb) Multiome | 366 | |
| chr19:49,331,677–49,331,877 | 6.5 kb | Proximal (<10kb) | 205 | |
| chr19:49,337,997–49,340,482 | 30.3 kb | Distal (>10kb) Multiome | 612 | |
| chr19:49,361,283–49,362,837 | 52.6 kb | Distal (>10kb) Multiome | 553 | |
| chr19:49,362,970–49,364,306 | 54.7 kb | Distal (>10kb) Multiome | 616 | |
| chr19:49,403,611–49,404,247 | 95.0 kb | Distal (>10kb) Multiome | 305 | |
| chr19:49,442,072–49,444,054 | 134.0 kb | Distal (>10kb) Multiome | 914 | |
| chr19:49,451,347–49,452,239 | 142.9 kb | Distal (>10kb) Multiome | 764 | |
| chr19:49,452,723–49,453,850 | 144.4 kb | Distal (>10kb) Multiome | 847 | |
| chr19:49,476,063–49,476,551 | 167.4 kb | Distal (>10kb) Multiome | 244 | |
| chr19:49,487,027–49,488,279 | 178.5 kb | Distal (>10kb) Multiome | 964 | |
| chr19:49,495,613–49,496,661 | 187.3 kb | Distal (>10kb) Multiome | 919 | |
| chr19:49,512,565–49,513,700 | 204.1 kb | Distal (>10kb) Multiome | 655 | |
| chr19:49,527,651–49,528,221 | 219.0 kb | Distal (>10kb) Multiome | 354 | |
| chr19:49,533,232–49,534,476 | 225.1 kb | Distal (>10kb) Multiome | 534 | |
| chr19:49,555,629–49,557,180 | 247.2 kb | Distal (>10kb) Multiome | 294 | |
| chr19:49,580,125–49,580,813 | 271.7 kb | Distal (>10kb) Multiome | 848 | |
| chr19:49,589,601–49,594,008 | 284.6 kb | Distal (>10kb) Multiome | 994 |
Genomic view of the SLC6A16 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.