The protein encoded by this gene is a gamma-aminobutyric acid (GABA) transporter that localizes to the plasma membrane. The encoded protein removes GABA from the synaptic cleft, restoring it to presynaptic terminals. [provided by RefSeq, Jan 2017]
Transcription factors with Perturb-seq knockdown data for SLC6A1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SLC6A1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SLC6A1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:10,707,403–10,708,599 | 284.3 kb | Distal (>10kb) Multiome | 168 | |
| chr3:10,738,686–10,739,159 | 253.2 kb | Distal (>10kb) Multiome | 335 | |
| chr3:10,815,921–10,816,782 | 175.9 kb | Distal (>10kb) Multiome | 379 | |
| chr3:10,983,264–10,983,769 | 8.4 kb | Proximal (<10kb) | 201 | |
| chr3:10,988,987–10,989,355 | 2.8 kb | Proximal (<10kb) | 22 | |
| chr3:10,989,698–10,990,161 | 2.0 kb | Proximal (<10kb) | 11 | |
| chr3:10,991,947–10,993,536 | 367 bp | At TSS Multiome | 207 | |
| chr3:11,060,631–11,061,882 | 68.8 kb | Distal (>10kb) Multiome | 335 | |
| chr3:11,271,956–11,272,823 | 280.2 kb | Distal (>10kb) Multiome | 826 |
Genomic view of the SLC6A1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.