The protein encoded by this gene is a membrane protein that functions to transport sodium and bicarbonate ions across the cell membrane. The encoded protein is important for pH regulation in neurons. The activity of this protein can be inhibited by 4,4'-Di-isothiocyanatostilbene-2,2'-disulfonic acid (DIDS). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]
Transcription factors with Perturb-seq knockdown data for SLC4A8. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SLC4A8 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SLC4A8, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:51,172,263–51,173,510 | 251.8 kb | Distal (>10kb) Multiome | 853 | |
| chr12:51,217,044–51,218,599 | 206.7 kb | Distal (>10kb) Multiome | 687 | |
| chr12:51,238,201–51,239,451 | 185.9 kb | Distal (>10kb) Multiome | 891 | |
| chr12:51,269,409–51,270,816 | 154.9 kb | Distal (>10kb) Multiome | 750 | |
| chr12:51,320,220–51,321,248 | 103.9 kb | Distal (>10kb) Multiome | 315 | |
| chr12:51,371,336–51,371,863 | 53.2 kb | Distal (>10kb) Multiome | 431 | |
| chr12:51,386,423–51,386,739 | 4.6 kb | Proximal (<10kb) | 50 | |
| chr12:51,390,937–51,392,088 | 33.3 kb | Distal (>10kb) Multiome | 504 | |
| chr12:51,392,705–51,392,862 | 1.4 kb | Proximal (<10kb) | 134 | |
| chr12:51,395,449–51,396,000 | 29.1 kb | Distal (>10kb) Multiome | 274 | |
| chr12:51,421,353–51,421,563 | 3.3 kb | Proximal (<10kb) | 130 | |
| chr12:51,424,595–51,425,524 | 99 bp | At TSS Multiome | 499 | |
| chr12:51,427,788–51,428,065 | 3.0 kb | Proximal (<10kb) | 13 | |
| chr12:51,590,353–51,591,928 | 166.2 kb | Distal (>10kb) Multiome HiCAR | 596 | |
| chr12:51,813,977–51,815,076 | 389.6 kb | Distal (>10kb) Multiome HiCAR | 486 | |
| chr12:51,820,355–51,822,541 | 396.1 kb | Distal (>10kb) Multiome HiCAR | 412 |
Genomic view of the SLC4A8 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.