Predicted to enable copper ion transmembrane transporter activity and zinc ion transmembrane transporter activity. Predicted to be involved in zinc ion transmembrane transport. Predicted to be located in Golgi apparatus; nucleus; and plasma membrane. Predicted to be active in membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for SLC39A11. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SLC39A11 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SLC39A11, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:72,816,220–72,816,808 | 276.1 kb | Distal (>10kb) Multiome | 55 | |
| chr17:73,092,145–73,093,083 | 25 bp | At TSS Multiome | 900 | |
| chr17:73,156,070–73,156,871 | 63.7 kb | Distal (>10kb) Multiome | 439 | |
| chr17:73,160,789–73,161,852 | 68.6 kb | Distal (>10kb) Multiome | 148 | |
| chr17:73,164,283–73,166,339 | 72.2 kb | Distal (>10kb) Multiome | 454 | |
| chr17:73,192,033–73,193,741 | 100.3 kb | Distal (>10kb) Multiome | 877 | |
| chr17:73,231,620–73,233,239 | 139.7 kb | Distal (>10kb) Multiome | 964 | |
| chr17:73,310,270–73,312,686 | 218.2 kb | Distal (>10kb) Multiome | 1078 | |
| chr17:73,317,321–73,317,925 | 224.9 kb | Distal (>10kb) Multiome | 153 | |
| chr17:73,318,653–73,319,222 | 226.3 kb | Distal (>10kb) Multiome | 44 | |
| chr17:73,341,495–73,342,744 | 249.5 kb | Distal (>10kb) Multiome | 347 | |
| chr17:73,342,845–73,343,860 | 250.8 kb | Distal (>10kb) Multiome | 294 | |
| chr17:73,351,620–73,352,260 | 259.3 kb | Distal (>10kb) Multiome | 17 | |
| chr17:73,359,891–73,361,657 | 268.5 kb | Distal (>10kb) Multiome | 310 | |
| chr17:73,363,301–73,364,389 | 271.3 kb | Distal (>10kb) Multiome | 140 |
Genomic view of the SLC39A11 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.