This gene encodes a member of the zinc-iron permease family. The encoded protein is localized to the cell membrane and acts as a zinc uptake transporter. This gene has been linked to prostate cancer, breast cancer, and Alzheimer's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012]
Transcription factors with Perturb-seq knockdown data for SLC39A1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SLC39A1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SLC39A1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:153,670,709–153,671,992 | 292.3 kb | Distal (>10kb) Multiome | 884 | |
| chr1:153,697,776–153,698,654 | 265.1 kb | Distal (>10kb) Multiome | 313 | |
| chr1:153,727,492–153,728,827 | 235.6 kb | Distal (>10kb) Multiome | 702 | |
| chr1:153,736,782–153,737,426 | 226.4 kb | Distal (>10kb) Multiome | 10 | |
| chr1:153,745,487–153,745,959 | 217.8 kb | Distal (>10kb) Multiome | 55 | |
| chr1:153,774,962–153,776,698 | 188.3 kb | Distal (>10kb) Multiome | 671 | |
| chr1:153,783,341–153,784,300 | 179.8 kb | Distal (>10kb) Multiome | 794 | |
| chr1:153,922,213–153,923,779 | 40.4 kb | Distal (>10kb) Multiome | 856 | |
| chr1:153,945,717–153,947,118 | 16.8 kb | Distal (>10kb) Multiome | 866 | |
| chr1:153,957,828–153,959,103 | 4.8 kb | Proximal (<10kb) Multiome | 912 | |
| chr1:153,963,107–153,964,407 | 161 bp | At TSS Multiome | 798 | |
| chr1:153,966,072–153,966,650 | 2.6 kb | Proximal (<10kb) | 97 | |
| chr1:153,967,147–153,968,324 | 4.2 kb | Proximal (<10kb) Multiome | 986 | |
| chr1:153,977,057–153,978,034 | 14.1 kb | Distal (>10kb) Multiome | 853 | |
| chr1:153,985,902–153,987,184 | 23.0 kb | Distal (>10kb) Multiome | 572 | |
| chr1:153,990,402–153,991,082 | 27.3 kb | Distal (>10kb) Multiome | 950 | |
| chr1:154,182,339–154,183,774 | 219.8 kb | Distal (>10kb) Multiome | 934 | |
| chr1:154,220,079–154,221,864 | 257.3 kb | Distal (>10kb) Multiome | 1071 |
Genomic view of the SLC39A1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.