Predicted to enable antiporter activity. Predicted to be involved in transmembrane transport. Predicted to act upstream of or within blastocyst hatching. Predicted to be located in membrane. Predicted to be active in Golgi apparatus. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for SLC35E2B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SLC35E2B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SLC35E2B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:1,398,861–1,399,955 | 293.3 kb | Distal (>10kb) Multiome | 879 | |
| chr1:1,406,992–1,407,823 | 285.5 kb | Distal (>10kb) Multiome | 938 | |
| chr1:1,435,318–1,436,066 | 257.1 kb | Distal (>10kb) Multiome | 511 | |
| chr1:1,511,442–1,512,404 | 180.8 kb | Distal (>10kb) Multiome | 897 | |
| chr1:1,540,164–1,541,317 | 152.2 kb | Distal (>10kb) Multiome | 195 | |
| chr1:1,573,904–1,575,432 | 118.0 kb | Distal (>10kb) Multiome | 949 | |
| chr1:1,599,945–1,600,642 | 92.8 kb | Distal (>10kb) Multiome | 307 | |
| chr1:1,615,103–1,616,799 | 77.3 kb | Distal (>10kb) Multiome | 951 | |
| chr1:1,628,379–1,632,529 | 62.7 kb | Distal (>10kb) Multiome | 552 | |
| chr1:1,658,722–1,659,418 | 33.7 kb | Distal (>10kb) Multiome | 602 | |
| chr1:1,692,460–1,692,603 | 191 bp | At TSS | 131 | |
| chr1:1,693,045–1,693,437 | 250 bp | At TSS | 142 | |
| chr1:1,724,054–1,724,738 | 31.6 kb | Distal (>10kb) Multiome | 631 | |
| chr1:1,777,637–1,780,173 | 86.0 kb | Distal (>10kb) Multiome | 970 | |
| chr1:1,782,008–1,783,229 | 89.5 kb | Distal (>10kb) Multiome | 590 | |
| chr1:1,883,184–1,883,831 | 190.8 kb | Distal (>10kb) Multiome | 303 | |
| chr1:1,890,319–1,891,952 | 198.5 kb | Distal (>10kb) Multiome | 748 | |
| chr1:1,908,308–1,910,312 | 216.4 kb | Distal (>10kb) Multiome | 801 | |
| chr1:1,918,258–1,920,500 | 226.7 kb | Distal (>10kb) Multiome | 820 | |
| chr1:1,959,901–1,960,517 | 267.4 kb | Distal (>10kb) Multiome | 594 |
Genomic view of the SLC35E2B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.