This gene encodes a transmembrane protein which belongs to subfamily 35A of the solute carrier superfamily. The encoded protein is a nucleoside-sugar transporter. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2017]
Transcription factors with Perturb-seq knockdown data for SLC35A5. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SLC35A5 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SLC35A5, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:112,136,789–112,137,394 | 425.0 kb | Distal (>10kb) Multiome HiCAR | 233 | |
| chr3:112,293,399–112,294,560 | 268.2 kb | Distal (>10kb) Multiome | 304 | |
| chr3:112,302,106–112,304,027 | 258.7 kb | Distal (>10kb) Multiome HiCAR | 204 | |
| chr3:112,321,650–112,322,563 | 239.9 kb | Distal (>10kb) Multiome | 210 | |
| chr3:112,332,830–112,333,873 | 228.8 kb | Distal (>10kb) Multiome | 281 | |
| chr3:112,390,974–112,391,552 | 170.8 kb | Distal (>10kb) Multiome | 215 | |
| chr3:112,399,211–112,401,142 | 161.6 kb | Distal (>10kb) Multiome | 175 | |
| chr3:112,560,905–112,563,207 | 47 bp | At TSS Multiome | 967 | |
| chr3:112,564,307–112,565,127 | 2.2 kb | Proximal (<10kb) | 17 | |
| chr3:112,566,578–112,566,873 | 4.5 kb | Proximal (<10kb) | 8 | |
| chr3:112,785,378–112,786,966 | 224.2 kb | Distal (>10kb) Multiome | 290 | |
| chr3:113,018,819–113,020,010 | 457.6 kb | Distal (>10kb) Multiome HiCAR | 965 |
Genomic view of the SLC35A5 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.