This gene belongs to a family of integral membrane proteins and encodes a protein that is involved in lipid metabolism. The increased expression of this gene in human neural stem cells derived from induced pluripotent stem cells suggests that it plays an important role in early brain development. Naturally occurring mutations in this gene are associated with autism spectrum disorders. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2017]
Transcription factors with Perturb-seq knockdown data for SLC27A3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SLC27A3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SLC27A3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:153,494,904–153,495,543 | 280.2 kb | Distal (>10kb) Multiome | 290 | |
| chr1:153,532,833–153,533,594 | 242.1 kb | Distal (>10kb) Multiome | 493 | |
| chr1:153,538,198–153,538,657 | 236.8 kb | Distal (>10kb) Multiome | 338 | |
| chr1:153,544,844–153,545,543 | 230.1 kb | Distal (>10kb) Multiome | 575 | |
| chr1:153,568,278–153,569,058 | 206.6 kb | Distal (>10kb) Multiome | 641 | |
| chr1:153,612,574–153,613,563 | 162.2 kb | Distal (>10kb) Multiome | 388 | |
| chr1:153,626,535–153,627,974 | 147.8 kb | Distal (>10kb) Multiome | 697 | |
| chr1:153,633,575–153,634,639 | 141.2 kb | Distal (>10kb) Multiome | 998 | |
| chr1:153,658,331–153,659,230 | 116.6 kb | Distal (>10kb) Multiome | 746 | |
| chr1:153,670,709–153,671,992 | 104.2 kb | Distal (>10kb) Multiome HiCAR | 884 | |
| chr1:153,697,776–153,698,654 | 77.0 kb | Distal (>10kb) Multiome | 313 | |
| chr1:153,727,492–153,728,827 | 47.4 kb | Distal (>10kb) Multiome | 702 | |
| chr1:153,736,782–153,737,426 | 38.2 kb | Distal (>10kb) Multiome | 10 | |
| chr1:153,745,487–153,745,959 | 29.7 kb | Distal (>10kb) Multiome | 55 | |
| chr1:153,771,941–153,772,182 | 3.1 kb | Proximal (<10kb) | 97 | |
| chr1:153,774,962–153,776,698 | 105 bp | At TSS Multiome | 671 | |
| chr1:153,783,341–153,784,300 | 8.4 kb | Proximal (<10kb) Multiome | 794 | |
| chr1:153,922,213–153,923,779 | 147.8 kb | Distal (>10kb) Multiome | 856 | |
| chr1:153,945,717–153,947,118 | 171.4 kb | Distal (>10kb) Multiome | 866 | |
| chr1:153,957,828–153,959,103 | 183.3 kb | Distal (>10kb) Multiome | 912 | |
| chr1:153,963,107–153,964,407 | 188.3 kb | Distal (>10kb) Multiome | 798 | |
| chr1:153,967,147–153,968,324 | 192.3 kb | Distal (>10kb) Multiome | 986 | |
| chr1:153,977,057–153,978,034 | 202.3 kb | Distal (>10kb) Multiome | 853 | |
| chr1:153,985,902–153,987,184 | 211.1 kb | Distal (>10kb) Multiome | 572 | |
| chr1:153,990,402–153,991,082 | 215.4 kb | Distal (>10kb) Multiome | 950 |
Genomic view of the SLC27A3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.