SLC25A33

solute carrier family 25 member 33 | BMSC-MCP, MGC4399, PNC1

SLC25A33 belongs to the SLC25 family of mitochondrial carrier proteins (Haitina et al., 2006 [PubMed 16949250]).[supplied by OMIM, Mar 2008]

Member of: DE-5

Biological processes 27 terms

cellular response to insulin stimulus (GO:0032869)cellular response to insulin-like growth factor stimulus (GO:1990314)mitochondria-nucleus signaling pathway (GO:0031930)mitochondria-nucleus signaling pathway (GO:0031930)mitochondrial inner membrane (GO:0005743)mitochondrial membrane (GO:0031966)mitochondrial membrane (GO:0031966)mitochondrial respiratory chain complex III assembly (GO:0034551)mitochondrial transcription (GO:0006390)mitochondrion (GO:0005739)mitochondrion (GO:0005739)mitochondrion organization (GO:0007005)nucleotide transport (GO:0006862)positive regulation of cell growth (GO:0030307)positive regulation of cell growth (GO:0030307)positive regulation of cell growth (GO:0030307)positive regulation of cell population proliferation (GO:0008284)pyrimidine nucleotide import into mitochondrion (GO:1990519)pyrimidine nucleotide import into mitochondrion (GO:1990519)pyrimidine nucleotide import into mitochondrion (GO:1990519)pyrimidine nucleotide import into mitochondrion (GO:1990519)pyrimidine nucleotide import into mitochondrion (GO:1990519)pyrimidine nucleotide transmembrane transporter activity (GO:0015218)pyrimidine nucleotide transmembrane transporter activity (GO:0015218)pyrimidine nucleotide transmembrane transporter activity (GO:0015218)regulation of oxidative phosphorylation (GO:0002082)regulation of reactive oxygen species biosynthetic process (GO:1903426)

Expression (TPM)

TFs regulating SLC25A33 0 TFs

Transcription factors with Perturb-seq knockdown data for SLC25A33. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SLC25A33 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to SLC25A33

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SLC25A33, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr1:9,292,267–9,293,831	246.7 kb	Distal (>10kb) Multiome	521
chr1:9,319,794–9,320,541	219.3 kb	Distal (>10kb) Multiome	91
chr1:9,374,739–9,375,309	164.5 kb	Distal (>10kb) Multiome	121
chr1:9,428,560–9,429,575	110.5 kb	Distal (>10kb) Multiome	815
chr1:9,495,048–9,495,686	44.1 kb	Distal (>10kb) Multiome	606
chr1:9,538,797–9,540,343	83 bp	At TSS Multiome	879
chr1:9,588,272–9,589,797	49.2 kb	Distal (>10kb) Multiome	633
chr1:9,593,403–9,593,904	54.1 kb	Distal (>10kb) Multiome	326
chr1:9,627,002–9,627,511	87.7 kb	Distal (>10kb) Multiome	773
chr1:9,651,631–9,652,549	112.6 kb	Distal (>10kb) Multiome	373
chr1:9,687,158–9,688,089	148.2 kb	Distal (>10kb) Multiome	575
chr1:9,688,950–9,690,301	150.1 kb	Distal (>10kb) Multiome	585
chr1:9,823,213–9,824,739	284.6 kb	Distal (>10kb) Multiome	652

Genome Browser

Genomic view of the SLC25A33 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.