This gene encodes a nuclear-encoded mitochondrial protein that is a member of the large family of solute carrier family 25 (SLC25) mitochondrial transporters. The members of this superfamily are involved in numerous metabolic pathways and cell functions. This gene product was previously reported to be a mitochondrial carnitine-acylcarnitine-like (CACL) translocase (PMID:128829710) or an ornithine transporter (designated ORNT3, PMID:19287344), however, a recent study characterized the main role of this protein as a mitochondrial transporter of basic amino acids, with a preference for arginine and lysine (PMID:24652292). Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Apr 2014]
Transcription factors with Perturb-seq knockdown data for SLC25A29. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SLC25A29 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SLC25A29, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:100,108,167–100,108,638 | 198.0 kb | Distal (>10kb) Multiome | 372 | |
| chr14:100,159,111–100,160,199 | 146.7 kb | Distal (>10kb) Multiome | 345 | |
| chr14:100,192,488–100,193,700 | 113.4 kb | Distal (>10kb) Multiome | 969 | |
| chr14:100,213,903–100,215,015 | 91.9 kb | Distal (>10kb) Multiome | 857 | |
| chr14:100,221,397–100,222,394 | 84.6 kb | Distal (>10kb) Multiome | 448 | |
| chr14:100,237,942–100,240,742 | 67.7 kb | Distal (>10kb) Multiome | 894 | |
| chr14:100,284,345–100,286,145 | 21.0 kb | Distal (>10kb) Multiome | 894 | |
| chr14:100,304,634–100,307,624 | 1.4 kb | Proximal (<10kb) Multiome | 725 | |
| chr14:100,318,097–100,318,705 | 12.0 kb | Distal (>10kb) Multiome | 363 | |
| chr14:100,348,695–100,349,830 | 42.9 kb | Distal (>10kb) Multiome | 195 | |
| chr14:100,371,470–100,372,320 | 65.6 kb | Distal (>10kb) Multiome HiCAR | 99 | |
| chr14:100,372,706–100,373,117 | 66.5 kb | Distal (>10kb) Multiome HiCAR | 79 | |
| chr14:100,375,470–100,376,763 | 69.9 kb | Distal (>10kb) Multiome HiCAR | 889 | |
| chr14:100,393,734–100,394,422 | 87.6 kb | Distal (>10kb) Multiome | 66 | |
| chr14:100,546,059–100,547,136 | 240.1 kb | Distal (>10kb) Multiome | 334 |
Genomic view of the SLC25A29 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.