This gene is a member of the mitochondrial carrier family. The encoded protein contains four EF-hand Ca(2+) binding motifs in the N-terminal domain, and localizes to mitochondria. The protein catalyzes the exchange of aspartate for glutamate and a proton across the inner mitochondrial membrane, and is stimulated by calcium on the external side of the inner mitochondrial membrane. Mutations in this gene result in citrullinemia, type II. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]
Transcription factors with Perturb-seq knockdown data for SLC25A13. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SLC25A13 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SLC25A13, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:96,143,465–96,144,397 | 178.2 kb | Distal (>10kb) Multiome | 316 | |
| chr7:96,302,968–96,303,866 | 18.7 kb | Distal (>10kb) Multiome | 601 | |
| chr7:96,314,164–96,315,310 | 7.4 kb | Proximal (<10kb) Multiome | 235 | |
| chr7:96,316,777–96,317,635 | 4.8 kb | Proximal (<10kb) Multiome | 155 | |
| chr7:96,321,109–96,322,695 | 633 bp | At TSS Multiome | 1117 | |
| chr7:96,354,497–96,355,496 | 33.1 kb | Distal (>10kb) Multiome | 182 | |
| chr7:96,591,576–96,592,853 | 269.8 kb | Distal (>10kb) Multiome | 120 | |
| chr7:97,016,407–97,017,582 | 694.7 kb | Distal (>10kb) Multiome HiCAR | 599 | |
| chr7:97,023,662–97,025,361 | 702.5 kb | Distal (>10kb) Multiome HiCAR | 445 |
Genomic view of the SLC25A13 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.