The absorption of vitamin C into the body and its distribution to organs requires two sodium-dependent vitamin C transporters. This gene encodes one of the two required transporters and the encoded protein accounts for tissue-specific uptake of vitamin C. Previously, this gene had an official symbol of SLC23A1. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for SLC23A2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SLC23A2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SLC23A2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr20:4,760,641–4,761,305 | 240.7 kb | Distal (>10kb) Multiome | 682 | |
| chr20:4,822,174–4,824,353 | 177.9 kb | Distal (>10kb) Multiome | 588 | |
| chr20:4,912,668–4,913,330 | 88.5 kb | Distal (>10kb) Multiome | 53 | |
| chr20:5,000,957–5,002,039 | 80 bp | At TSS Multiome | 553 | |
| chr20:5,002,152–5,002,348 | 642 bp | At TSS | 98 | |
| chr20:5,112,796–5,113,601 | 111.7 kb | Distal (>10kb) Multiome | 1034 | |
| chr20:5,119,153–5,120,492 | 118.5 kb | Distal (>10kb) Multiome | 1100 | |
| chr20:5,126,122–5,128,043 | 125.3 kb | Distal (>10kb) Multiome | 1011 |
Genomic view of the SLC23A2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.