SLC22A23 belongs to a large family of transmembrane proteins that function as uniporters, symporters, and antiporters to transport organic ions across cell membranes (Jacobsson et al., 2007 [PubMed 17714910]).[supplied by OMIM, Mar 2008]
Transcription factors with Perturb-seq knockdown data for SLC22A23. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SLC22A23 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SLC22A23, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:3,156,701–3,158,249 | 299.4 kb | Distal (>10kb) Multiome | 859 | |
| chr6:3,162,506–3,163,526 | 294.1 kb | Distal (>10kb) Multiome | 926 | |
| chr6:3,165,678–3,166,637 | 290.7 kb | Distal (>10kb) Multiome | 343 | |
| chr6:3,226,566–3,229,919 | 229.3 kb | Distal (>10kb) Multiome | 770 | |
| chr6:3,231,202–3,232,265 | 225.3 kb | Distal (>10kb) Multiome | 593 | |
| chr6:3,251,328–3,252,273 | 205.3 kb | Distal (>10kb) Multiome | 561 | |
| chr6:3,258,552–3,259,886 | 198.1 kb | Distal (>10kb) Multiome | 946 | |
| chr6:3,356,075–3,356,744 | 100.7 kb | Distal (>10kb) Multiome | 475 | |
| chr6:3,414,872–3,415,397 | 41.9 kb | Distal (>10kb) Multiome | 265 | |
| chr6:3,423,549–3,424,168 | 33.2 kb | Distal (>10kb) Multiome | 107 | |
| chr6:3,455,491–3,458,021 | 28 bp | At TSS Multiome | 809 | |
| chr6:3,511,478–3,512,074 | 54.6 kb | Distal (>10kb) Multiome | 323 | |
| chr6:3,750,069–3,752,509 | 295.0 kb | Distal (>10kb) Multiome | 815 |
Genomic view of the SLC22A23 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.