This gene encodes a member of a family of solute transporter proteins. The membrane-bound protein is the principal transporter that clears the excitatory neurotransmitter glutamate from the extracellular space at synapses in the central nervous system. Glutamate clearance is necessary for proper synaptic activation and to prevent neuronal damage from excessive activation of glutamate receptors. Improper regulation of this gene is thought to be associated with several neurological disorders. Alternatively spliced transcript variants of this gene have been identified. [provided by RefSeq, Jun 2017]
Transcription factors with Perturb-seq knockdown data for SLC1A2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SLC1A2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SLC1A2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:35,392,285–35,392,527 | at TSS | At TSS | 300 | |
| chr11:35,400,858–35,401,315 | 8.5 kb | Proximal (<10kb) | 32 | |
| chr11:35,402,638–35,403,312 | 1.2 kb | Proximal (<10kb) | 55 | |
| chr11:35,404,360–35,404,755 | at TSS | At TSS | 192 | |
| chr11:35,412,426–35,412,583 | 7.9 kb | Proximal (<10kb) | 43 | |
| chr11:35,418,192–35,419,975 | at TSS | At TSS | 384 | |
| chr11:35,420,184–35,420,680 | 1.5 kb | Proximal (<10kb) | 83 |
Genomic view of the SLC1A2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.