This gene encodes a protein, which has high sequence similarity to rat, xenopus and zebrafish proteins. The protein function is unknown. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for SLC18B1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SLC18B1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SLC18B1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:132,512,567–132,513,614 | 285.6 kb | Distal (>10kb) Multiome | 923 | |
| chr6:132,767,648–132,768,685 | 30.4 kb | Distal (>10kb) Multiome | 388 | |
| chr6:132,798,131–132,799,261 | 59 bp | At TSS Multiome | 846 | |
| chr6:132,813,124–132,815,456 | 15.8 kb | Distal (>10kb) Multiome | 1156 | |
| chr6:132,820,314–132,821,624 | 22.2 kb | Distal (>10kb) Multiome | 402 |
Genomic view of the SLC18B1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.