This gene is thought to be a candidate for psoriasis susceptibility. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Sep 2010]
Transcription factors with Perturb-seq knockdown data for SLC12A8. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SLC12A8 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SLC12A8, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:125,055,367–125,056,705 | 156.6 kb | Distal (>10kb) Multiome | 524 | |
| chr3:125,120,569–125,121,347 | 91.8 kb | Distal (>10kb) Multiome | 178 | |
| chr3:125,141,761–125,142,375 | 70.7 kb | Distal (>10kb) Multiome | 228 | |
| chr3:125,155,911–125,156,374 | 56.7 kb | Distal (>10kb) Multiome | 134 | |
| chr3:125,211,780–125,213,160 | 354 bp | At TSS Multiome | 258 | |
| chr3:125,357,135–125,357,657 | 144.6 kb | Distal (>10kb) Multiome | 492 | |
| chr3:125,374,544–125,375,878 | 162.5 kb | Distal (>10kb) Multiome | 864 |
Genomic view of the SLC12A8 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.