The protein encoded by this gene shares homology with Src kinase-associated phosphoprotein 1, and is a substrate of Src family kinases. It is an adaptor protein that is thought to play an essential role in the Src signaling pathway, and in regulating proper activation of the immune system. This protein contains an amino terminal coiled-coil domain for self-dimerization, a plecskstrin homology (PH) domain required for interactions with lipids at the membrane, and a Src homology (SH3) domain at the carboxy terminus. Some reports indicate that this protein inhibits actin polymerization through interactions with actin assembly factors, and might negatively regulate the invasiveness of tumors by modulating actin assembly. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2015]
Transcription factors with Perturb-seq knockdown data for SKAP2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SKAP2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SKAP2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:26,857,502–26,857,903 | 6.7 kb | Proximal (<10kb) | 166 | |
| chr7:26,858,849–26,859,047 | 5.5 kb | Proximal (<10kb) | 31 | |
| chr7:26,863,879–26,865,253 | 135 bp | At TSS Multiome | 935 | |
| chr7:26,948,678–26,949,133 | 84.3 kb | Distal (>10kb) Multiome | 88 | |
| chr7:27,030,239–27,030,738 | 166.1 kb | Distal (>10kb) Multiome | 62 | |
| chr7:27,087,824–27,088,552 | 223.6 kb | Distal (>10kb) Multiome | 142 | |
| chr7:27,095,780–27,096,930 | 231.7 kb | Distal (>10kb) Multiome HiCAR | 507 | |
| chr7:27,130,102–27,131,436 | 266.3 kb | Distal (>10kb) Multiome HiCAR | 676 | |
| chr7:27,142,662–27,144,027 | 279.2 kb | Distal (>10kb) Multiome HiCAR | 563 | |
| chr7:27,150,502–27,151,347 | 286.4 kb | Distal (>10kb) Multiome | 628 | |
| chr7:27,155,973–27,156,855 | 292.0 kb | Distal (>10kb) Multiome | 318 | |
| chr7:27,160,568–27,161,432 | 296.4 kb | Distal (>10kb) Multiome | 613 |
Genomic view of the SKAP2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.