This gene encodes a component of the spindle and kinetochore-associated protein complex that regulates microtubule attachment to the kinetochores during mitosis. The encoded protein localizes to the outer kinetechore and may be required for normal chromosome segregation and cell division. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]
Transcription factors with Perturb-seq knockdown data for SKA3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SKA3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SKA3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr13:20,902,026–20,903,305 | 273.7 kb | Distal (>10kb) Multiome | 749 | |
| chr13:21,060,253–21,061,988 | 115.0 kb | Distal (>10kb) Multiome | 817 | |
| chr13:21,075,367–21,076,193 | 100.7 kb | Distal (>10kb) Multiome | 151 | |
| chr13:21,139,877–21,141,067 | 36.1 kb | Distal (>10kb) Multiome | 784 | |
| chr13:21,176,109–21,177,241 | 88 bp | At TSS Multiome | 933 | |
| chr13:21,297,800–21,298,863 | 121.7 kb | Distal (>10kb) Multiome | 776 | |
| chr13:21,326,200–21,327,030 | 150.1 kb | Distal (>10kb) Multiome | 179 | |
| chr13:21,410,303–21,410,800 | 234.1 kb | Distal (>10kb) Multiome | 76 | |
| chr13:21,458,471–21,459,892 | 282.9 kb | Distal (>10kb) Multiome | 682 |
Genomic view of the SKA3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.