Enables microtubule binding activity. Involved in attachment of mitotic spindle microtubules to kinetochore; negative regulation of mitotic spindle assembly checkpoint signaling; and positive regulation of microtubule polymerization. Located in several cellular components, including intercellular bridge; kinetochore; and microtubule cytoskeleton. Part of SKA complex. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for SKA1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SKA1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SKA1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr18:50,194,148–50,195,562 | 179.9 kb | Distal (>10kb) Multiome | 482 | |
| chr18:50,230,869–50,232,199 | 143.3 kb | Distal (>10kb) Multiome | 139 | |
| chr18:50,232,326–50,232,896 | 142.2 kb | Distal (>10kb) Multiome | 108 | |
| chr18:50,266,119–50,266,730 | 108.5 kb | Distal (>10kb) Multiome | 493 | |
| chr18:50,268,096–50,268,782 | 106.5 kb | Distal (>10kb) Multiome | 343 | |
| chr18:50,281,123–50,282,656 | 93.4 kb | Distal (>10kb) Multiome | 877 | |
| chr18:50,287,072–50,288,411 | 87.2 kb | Distal (>10kb) Multiome | 897 | |
| chr18:50,307,523–50,307,991 | 67.2 kb | Distal (>10kb) Multiome | 265 | |
| chr18:50,374,233–50,375,652 | 21 bp | At TSS Multiome | 732 | |
| chr18:50,398,965–50,399,883 | 24.2 kb | Distal (>10kb) Multiome | 106 | |
| chr18:50,559,125–50,561,284 | 185.0 kb | Distal (>10kb) Multiome | 350 |
Genomic view of the SKA1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.