Enables ATP binding activity; magnesium ion binding activity; and protein serine/threonine kinase activity. Involved in positive regulation of TORC1 signaling; positive regulation of TORC2 signaling; and protein phosphorylation. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for SIK3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SIK3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SIK3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:116,772,462–116,773,416 | 325.5 kb | Distal (>10kb) Multiome HiCAR | 928 | |
| chr11:116,791,118–116,791,887 | 307.0 kb | Distal (>10kb) Multiome HiCAR | 473 | |
| chr11:116,813,255–116,814,379 | 284.7 kb | Distal (>10kb) Multiome | 206 | |
| chr11:116,835,609–116,836,611 | 262.4 kb | Distal (>10kb) Multiome HiCAR | 666 | |
| chr11:117,096,514–117,096,926 | 1.5 kb | Proximal (<10kb) | 427 | |
| chr11:117,097,570–117,099,243 | 31 bp | At TSS Multiome | 739 | |
| chr11:117,099,458–117,100,103 | 1.5 kb | Proximal (<10kb) Multiome | 62 | |
| chr11:117,100,958–117,101,292 | 2.5 kb | Proximal (<10kb) | 11 | |
| chr11:117,106,090–117,106,253 | 7.7 kb | Proximal (<10kb) | 198 | |
| chr11:117,143,916–117,144,864 | 45.9 kb | Distal (>10kb) Multiome | 969 | |
| chr11:117,178,198–117,179,718 | 80.4 kb | Distal (>10kb) Multiome | 726 | |
| chr11:117,197,957–117,198,434 | 99.6 kb | Distal (>10kb) Multiome | 160 | |
| chr11:117,198,962–117,199,797 | 100.9 kb | Distal (>10kb) Multiome | 211 | |
| chr11:117,231,703–117,233,431 | 134.1 kb | Distal (>10kb) Multiome | 703 | |
| chr11:117,315,726–117,316,638 | 217.9 kb | Distal (>10kb) Multiome | 619 | |
| chr11:117,327,486–117,328,627 | 229.5 kb | Distal (>10kb) Multiome | 751 |
Genomic view of the SIK3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.