Involved in negative regulation of Toll signaling pathway. Located in membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for SIGIRR. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SIGIRR upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SIGIRR, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:206,950–208,051 | 209.9 kb | Distal (>10kb) Multiome | 884 | |
| chr11:208,471–209,205 | 208.5 kb | Distal (>10kb) Multiome | 593 | |
| chr11:235,864–237,255 | 180.9 kb | Distal (>10kb) Multiome | 874 | |
| chr11:288,466–289,320 | 128.3 kb | Distal (>10kb) Multiome | 400 | |
| chr11:313,383–314,476 | 103.5 kb | Distal (>10kb) Multiome | 421 | |
| chr11:316,978–318,064 | 100.2 kb | Distal (>10kb) Multiome | 100 | |
| chr11:333,722–334,610 | 83.1 kb | Distal (>10kb) Multiome | 238 | |
| chr11:355,654–356,479 | 61.2 kb | Distal (>10kb) Multiome | 894 | |
| chr11:370,037–370,556 | 47.2 kb | Distal (>10kb) Multiome | 205 | |
| chr11:406,008–408,661 | 10.1 kb | Distal (>10kb) Multiome | 587 | |
| chr11:416,764–417,613 | 6 bp | At TSS Multiome | 431 | |
| chr11:422,294–422,679 | 4.9 kb | Proximal (<10kb) | 131 | |
| chr11:447,919–448,752 | 30.9 kb | Distal (>10kb) Multiome | 808 | |
| chr11:449,838–451,194 | 32.9 kb | Distal (>10kb) Multiome | 836 | |
| chr11:506,153–507,989 | 89.8 kb | Distal (>10kb) Multiome | 977 | |
| chr11:534,525–536,399 | 118.3 kb | Distal (>10kb) Multiome | 673 | |
| chr11:536,654–537,918 | 120.1 kb | Distal (>10kb) Multiome | 558 | |
| chr11:554,380–556,321 | 137.8 kb | Distal (>10kb) Multiome | 460 | |
| chr11:559,830–562,079 | 143.5 kb | Distal (>10kb) Multiome | 791 | |
| chr11:567,850–569,533 | 151.2 kb | Distal (>10kb) Multiome | 672 | |
| chr11:574,830–576,748 | 158.8 kb | Distal (>10kb) Multiome | 793 | |
| chr11:613,334–614,059 | 196.4 kb | Distal (>10kb) Multiome | 215 | |
| chr11:615,262–616,320 | 198.6 kb | Distal (>10kb) Multiome | 443 | |
| chr11:636,786–637,700 | 219.8 kb | Distal (>10kb) Multiome | 161 | |
| chr11:693,835–696,330 | 278.1 kb | Distal (>10kb) Multiome | 873 | |
| chr11:705,737–706,270 | 288.7 kb | Distal (>10kb) Multiome | 361 |
Genomic view of the SIGIRR locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.