Predicted to enable phosphotyrosine residue binding activity. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for SHE. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SHE upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SHE, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:154,220,079–154,221,864 | 281.7 kb | Distal (>10kb) Multiome | 1071 | |
| chr1:154,272,082–154,272,847 | 229.9 kb | Distal (>10kb) Multiome | 834 | |
| chr1:154,324,640–154,326,731 | 177.6 kb | Distal (>10kb) Multiome | 685 | |
| chr1:154,328,267–154,328,890 | 173.8 kb | Distal (>10kb) Multiome | 261 | |
| chr1:154,352,626–154,353,487 | 149.2 kb | Distal (>10kb) Multiome | 466 | |
| chr1:154,404,987–154,406,067 | 97.0 kb | Distal (>10kb) Multiome | 731 | |
| chr1:154,479,920–154,480,111 | 9.1 kb | Proximal (<10kb) | 299 | |
| chr1:154,489,011–154,489,730 | 13.0 kb | Distal (>10kb) Multiome | 82 | |
| chr1:154,493,110–154,493,579 | 9.1 kb | Proximal (<10kb) Multiome | 134 | |
| chr1:154,501,716–154,502,717 | 236 bp | At TSS Multiome | 212 | |
| chr1:154,558,123–154,559,826 | 56.4 kb | Distal (>10kb) Multiome | 1173 | |
| chr1:154,567,476–154,568,396 | 65.5 kb | Distal (>10kb) Multiome | 774 | |
| chr1:154,607,914–154,609,125 | 106.3 kb | Distal (>10kb) Multiome | 720 | |
| chr1:154,627,216–154,628,267 | 125.4 kb | Distal (>10kb) Multiome | 850 | |
| chr1:154,683,607–154,684,346 | 181.6 kb | Distal (>10kb) Multiome | 39 | |
| chr1:154,760,465–154,760,941 | 258.2 kb | Distal (>10kb) Multiome | 418 |
Genomic view of the SHE locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.