This gene encodes a protein containing an N-terminus RING-finger, four SH3 domains, and a region implicated in binding of the Rho GTPase Rac. Via the RING-finger, the encoded protein has been shown to function as an ubiquitin-protein ligase involved in protein sorting at the trans-Golgi network. The encoded protein may also act as a scaffold for the c-Jun N-terminal kinase signaling pathway, facilitating the formation of a functional signaling module. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for SH3RF1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SH3RF1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SH3RF1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:169,009,429–169,010,942 | 260.6 kb | Distal (>10kb) Multiome | 829 | |
| chr4:169,069,656–169,070,749 | 200.7 kb | Distal (>10kb) Multiome | 482 | |
| chr4:169,100,408–169,101,097 | 170.2 kb | Distal (>10kb) Multiome | 151 | |
| chr4:169,267,159–169,267,573 | 3.4 kb | Proximal (<10kb) | 66 | |
| chr4:169,270,015–169,271,998 | 114 bp | At TSS Multiome | 735 | |
| chr4:169,334,284–169,334,914 | 63.6 kb | Distal (>10kb) Multiome | 96 | |
| chr4:169,347,007–169,347,496 | 76.3 kb | Distal (>10kb) Multiome | 18 |
Genomic view of the SH3RF1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.