Involved in cytoskeleton organization. Located in cytosol; nuclear body; and ruffle membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for SH3BGRL3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SH3BGRL3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SH3BGRL3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:25,997,628–25,998,708 | 281.9 kb | Distal (>10kb) Multiome | 1091 | |
| chr1:26,021,572–26,022,167 | 258.3 kb | Distal (>10kb) Multiome | 231 | |
| chr1:26,034,958–26,036,424 | 244.0 kb | Distal (>10kb) Multiome | 780 | |
| chr1:26,045,386–26,046,127 | 234.1 kb | Distal (>10kb) Multiome | 178 | |
| chr1:26,093,947–26,095,162 | 185.8 kb | Distal (>10kb) Multiome | 403 | |
| chr1:26,110,626–26,112,596 | 168.3 kb | Distal (>10kb) Multiome | 934 | |
| chr1:26,161,287–26,162,232 | 118.3 kb | Distal (>10kb) Multiome | 564 | |
| chr1:26,164,134–26,165,044 | 115.6 kb | Distal (>10kb) Multiome | 500 | |
| chr1:26,169,358–26,170,373 | 110.2 kb | Distal (>10kb) Multiome | 969 | |
| chr1:26,177,126–26,177,750 | 102.7 kb | Distal (>10kb) Multiome | 363 | |
| chr1:26,200,994–26,201,612 | 78.8 kb | Distal (>10kb) Multiome | 369 | |
| chr1:26,225,042–26,225,908 | 54.6 kb | Distal (>10kb) Multiome | 462 | |
| chr1:26,233,613–26,234,924 | 46.0 kb | Distal (>10kb) Multiome | 867 | |
| chr1:26,275,604–26,276,096 | 4.3 kb | Proximal (<10kb) Multiome | 373 | |
| chr1:26,279,438–26,280,566 | 112 bp | At TSS Multiome | 820 | |
| chr1:26,281,959–26,282,310 | 1.9 kb | Proximal (<10kb) | 158 | |
| chr1:26,285,166–26,285,375 | 5.1 kb | Proximal (<10kb) | 351 | |
| chr1:26,285,754–26,286,146 | 5.7 kb | Proximal (<10kb) | 155 | |
| chr1:26,306,331–26,306,935 | 26.6 kb | Distal (>10kb) Multiome | 563 | |
| chr1:26,335,993–26,337,256 | 56.5 kb | Distal (>10kb) Multiome | 655 | |
| chr1:26,360,031–26,360,668 | 80.3 kb | Distal (>10kb) Multiome | 164 | |
| chr1:26,409,125–26,412,949 | 130.4 kb | Distal (>10kb) Multiome HiCAR | 517 | |
| chr1:26,416,811–26,417,349 | 137.1 kb | Distal (>10kb) Multiome HiCAR | 290 | |
| chr1:26,418,111–26,419,646 | 139.1 kb | Distal (>10kb) Multiome HiCAR | 189 | |
| chr1:26,431,868–26,432,811 | 152.1 kb | Distal (>10kb) Multiome | 1083 | |
| chr1:26,471,339–26,473,364 | 192.9 kb | Distal (>10kb) Multiome | 992 | |
| chr1:26,500,060–26,501,704 | 220.3 kb | Distal (>10kb) Multiome | 1028 | |
| chr1:26,529,200–26,531,855 | 251.3 kb | Distal (>10kb) Multiome | 703 |
Genomic view of the SH3BGRL3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.