Predicted to be involved in meiotic sister chromatid cohesion. Predicted to act upstream of or within several processes, including meiotic nuclear division; meiotic sister chromatid cohesion; and positive regulation of maintenance of meiotic sister chromatid cohesion, centromeric. Located in chromosome, centromeric region and nuclear body. Part of mitotic cohesin complex. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for SGO2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SGO2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SGO2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:199,955,094–199,956,570 | 570.6 kb | Distal (>10kb) Multiome HiCAR | 1078 | |
| chr2:200,305,837–200,307,750 | 219.3 kb | Distal (>10kb) Multiome | 864 | |
| chr2:200,481,420–200,481,868 | 44.6 kb | Distal (>10kb) Multiome | 350 | |
| chr2:200,509,374–200,510,438 | 16.1 kb | Distal (>10kb) Multiome | 876 | |
| chr2:200,525,770–200,526,701 | 42 bp | At TSS Multiome | 869 | |
| chr2:200,585,716–200,586,842 | 59.9 kb | Distal (>10kb) Multiome | 627 | |
| chr2:200,648,397–200,649,297 | 122.6 kb | Distal (>10kb) Multiome | 229 | |
| chr2:200,713,048–200,713,472 | 187.1 kb | Distal (>10kb) Multiome | 763 | |
| chr2:200,736,302–200,737,549 | 210.8 kb | Distal (>10kb) Multiome | 210 | |
| chr2:200,810,854–200,812,782 | 285.4 kb | Distal (>10kb) Multiome | 1048 |
Genomic view of the SGO2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.