Predicted to enable citrate transmembrane transporter activity. Predicted to be involved in citrate transport and mitochondrial transmembrane transport. Located in mitochondrion. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for SFXN5. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SFXN5 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SFXN5, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:72,825,190–72,826,191 | 245.8 kb | Distal (>10kb) Multiome | 812 | |
| chr2:72,862,264–72,863,318 | 209.0 kb | Distal (>10kb) Multiome | 596 | |
| chr2:72,886,993–72,888,318 | 183.8 kb | Distal (>10kb) Multiome | 900 | |
| chr2:72,915,937–72,919,139 | 154.2 kb | Distal (>10kb) Multiome | 786 | |
| chr2:72,919,971–72,921,133 | 151.1 kb | Distal (>10kb) Multiome | 150 | |
| chr2:72,924,149–72,925,197 | 147.3 kb | Distal (>10kb) Multiome | 169 | |
| chr2:72,951,372–72,951,860 | 120.2 kb | Distal (>10kb) Multiome | 115 | |
| chr2:72,963,185–72,963,825 | 108.1 kb | Distal (>10kb) Multiome | 135 | |
| chr2:73,070,503–73,072,300 | 187 bp | At TSS Multiome | 1016 | |
| chr2:73,111,353–73,113,710 | 41.4 kb | Distal (>10kb) Multiome | 903 | |
| chr2:73,156,488–73,157,075 | 85.1 kb | Distal (>10kb) Multiome | 419 | |
| chr2:73,175,306–73,176,433 | 104.0 kb | Distal (>10kb) Multiome | 499 | |
| chr2:73,176,845–73,177,711 | 105.8 kb | Distal (>10kb) Multiome | 779 | |
| chr2:73,202,161–73,203,581 | 130.8 kb | Distal (>10kb) Multiome | 227 | |
| chr2:73,214,088–73,214,797 | 142.6 kb | Distal (>10kb) Multiome | 870 | |
| chr2:73,232,770–73,234,882 | 162.8 kb | Distal (>10kb) Multiome | 1129 | |
| chr2:73,268,616–73,269,882 | 197.5 kb | Distal (>10kb) Multiome | 384 | |
| chr2:73,283,511–73,285,190 | 212.9 kb | Distal (>10kb) Multiome | 734 | |
| chr2:73,291,197–73,292,186 | 219.7 kb | Distal (>10kb) Multiome | 609 | |
| chr2:73,293,075–73,294,022 | 222.0 kb | Distal (>10kb) Multiome | 382 |
Genomic view of the SFXN5 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.