Predicted to enable lysine N-methyltransferase activity. Predicted to be involved in regulation of signal transduction by p53 class mediator. Located in mitochondrion. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for SETD9. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SETD9 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SETD9, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:56,814,407–56,817,107 | 94.2 kb | Distal (>10kb) Multiome | 908 | |
| chr5:56,900,925–56,901,114 | 8.5 kb | Proximal (<10kb) | 125 | |
| chr5:56,908,541–56,908,905 | 686 bp | At TSS | 176 | |
| chr5:56,909,110–56,910,601 | 233 bp | At TSS Multiome | 974 | |
| chr5:56,950,605–56,952,748 | 42.6 kb | Distal (>10kb) Multiome | 662 | |
| chr5:57,019,246–57,020,109 | 110.1 kb | Distal (>10kb) Multiome | 80 | |
| chr5:57,070,146–57,071,232 | 161.2 kb | Distal (>10kb) Multiome | 102 | |
| chr5:57,095,125–57,095,719 | 185.9 kb | Distal (>10kb) Multiome | 128 | |
| chr5:57,172,984–57,174,839 | 264.2 kb | Distal (>10kb) Multiome HiCAR | 992 | |
| chr5:58,459,176–58,461,210 | 1550.7 kb | Distal (>10kb) Multiome HiCAR | 896 |
Genomic view of the SETD9 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.