This gene encodes a member of the sestrin family of stress-induced proteins. The encoded protein reduces the levels of intracellular reactive oxygen species induced by activated Ras downstream of RAC-alpha serine/threonine-protein kinase (Akt) and FoxO transcription factor. The protein is required for normal regulation of blood glucose, insulin resistance and plays a role in lipid storage in obesity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2012]
Transcription factors with Perturb-seq knockdown data for SESN3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SESN3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SESN3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:94,973,096–94,974,006 | 257.6 kb | Distal (>10kb) Multiome | 740 | |
| chr11:95,066,821–95,068,191 | 163.8 kb | Distal (>10kb) Multiome | 721 | |
| chr11:95,089,389–95,090,696 | 141.4 kb | Distal (>10kb) Multiome | 660 | |
| chr11:95,107,207–95,108,126 | 123.5 kb | Distal (>10kb) Multiome | 232 | |
| chr11:95,144,387–95,145,222 | 86.3 kb | Distal (>10kb) Multiome | 127 | |
| chr11:95,149,652–95,152,295 | 81.3 kb | Distal (>10kb) Multiome | 685 | |
| chr11:95,229,933–95,232,611 | 108 bp | At TSS Multiome | 696 | |
| chr11:95,232,733–95,233,136 | 1.5 kb | Proximal (<10kb) | 73 | |
| chr11:95,235,300–95,235,760 | 4.1 kb | Proximal (<10kb) | 110 |
Genomic view of the SESN3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.