This gene encodes a member of the serpin family of proteins, a group of proteins that inhibit serine proteases. Thrombin, urokinase, plasmin and trypsin are among the proteases that this family member can inhibit. This gene is a susceptibility gene for chronic obstructive pulmonary disease and for emphysema. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]
Transcription factors with Perturb-seq knockdown data for SERPINE2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SERPINE2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SERPINE2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:223,836,841–223,838,450 | 201.7 kb | Distal (>10kb) Multiome | 742 | |
| chr2:223,944,141–223,945,550 | 94.0 kb | Distal (>10kb) Multiome | 1001 | |
| chr2:223,947,302–223,948,205 | 91.4 kb | Distal (>10kb) Multiome | 107 | |
| chr2:223,952,061–223,952,791 | 86.9 kb | Distal (>10kb) Multiome | 152 | |
| chr2:223,956,992–223,957,891 | 81.9 kb | Distal (>10kb) Multiome | 1093 | |
| chr2:224,026,729–224,027,840 | 12.0 kb | Distal (>10kb) Multiome | 186 | |
| chr2:224,038,254–224,040,391 | 150 bp | At TSS Multiome | 665 | |
| chr2:224,040,867–224,041,057 | 1.6 kb | Proximal (<10kb) | 15 | |
| chr2:224,045,624–224,045,771 | 6.3 kb | Proximal (<10kb) | 2 | |
| chr2:224,088,581–224,089,375 | 49.7 kb | Distal (>10kb) Multiome | 58 | |
| chr2:224,091,133–224,092,389 | 52.6 kb | Distal (>10kb) Multiome | 112 | |
| chr2:224,157,497–224,159,399 | 118.9 kb | Distal (>10kb) Multiome HiCAR | 160 |
Genomic view of the SERPINE2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.