Enables phospholipid scramblase activity. Involved in plasma membrane phospholipid scrambling. Located in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for SERINC2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SERINC2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SERINC2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:31,154,613–31,155,769 | 258.2 kb | Distal (>10kb) Multiome | 807 | |
| chr1:31,162,718–31,163,222 | 250.3 kb | Distal (>10kb) Multiome | 461 | |
| chr1:31,182,154–31,182,689 | 230.8 kb | Distal (>10kb) Multiome | 644 | |
| chr1:31,239,028–31,240,122 | 173.6 kb | Distal (>10kb) Multiome | 323 | |
| chr1:31,296,477–31,297,658 | 116.3 kb | Distal (>10kb) Multiome | 749 | |
| chr1:31,372,771–31,374,054 | 39.6 kb | Distal (>10kb) Multiome | 474 | |
| chr1:31,375,901–31,376,374 | 36.9 kb | Distal (>10kb) Multiome | 20 | |
| chr1:31,394,503–31,395,142 | 18.4 kb | Distal (>10kb) Multiome | 592 | |
| chr1:31,412,821–31,414,256 | 20 bp | At TSS Multiome | 550 | |
| chr1:31,422,803–31,422,985 | 9.6 kb | Proximal (<10kb) | 427 | |
| chr1:31,548,778–31,549,765 | 135.9 kb | Distal (>10kb) Multiome HiCAR | 641 | |
| chr1:31,617,603–31,618,426 | 205.0 kb | Distal (>10kb) Multiome | 345 | |
| chr1:31,644,333–31,645,606 | 231.8 kb | Distal (>10kb) Multiome | 926 | |
| chr1:31,647,107–31,647,947 | 234.4 kb | Distal (>10kb) Multiome | 49 | |
| chr1:31,703,931–31,704,503 | 290.9 kb | Distal (>10kb) Multiome | 217 | |
| chr1:33,338,430–33,338,960 | 1925.4 kb | Distal (>10kb) Multiome HiCAR | 254 |
Genomic view of the SERINC2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.