Predicted to enable hydrolase activity. Predicted to be located in cytoplasmic vesicle. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for SERHL2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SERHL2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SERHL2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr22:42,269,385–42,271,172 | 283.2 kb | Distal (>10kb) Multiome | 751 | |
| chr22:42,343,251–42,344,201 | 210.3 kb | Distal (>10kb) Multiome | 220 | |
| chr22:42,344,438–42,344,933 | 209.2 kb | Distal (>10kb) Multiome | 162 | |
| chr22:42,365,301–42,366,142 | 188.4 kb | Distal (>10kb) Multiome | 197 | |
| chr22:42,368,263–42,369,908 | 184.6 kb | Distal (>10kb) Multiome | 592 | |
| chr22:42,437,555–42,438,618 | 116.1 kb | Distal (>10kb) Multiome | 501 | |
| chr22:42,444,134–42,444,723 | 109.5 kb | Distal (>10kb) Multiome HiCAR | 574 | |
| chr22:42,499,840–42,501,072 | 53.5 kb | Distal (>10kb) Multiome HiCAR | 356 | |
| chr22:42,519,544–42,520,134 | 34.1 kb | Distal (>10kb) Multiome HiCAR | 330 | |
| chr22:42,547,880–42,548,293 | 5.6 kb | Proximal (<10kb) | 18 | |
| chr22:42,553,476–42,554,267 | 69 bp | At TSS Multiome | 514 | |
| chr22:42,560,947–42,561,111 | 7.0 kb | Proximal (<10kb) | 101 | |
| chr22:42,581,750–42,582,381 | 28.2 kb | Distal (>10kb) Multiome | 290 | |
| chr22:42,614,291–42,616,423 | 61.4 kb | Distal (>10kb) Multiome | 1280 | |
| chr22:42,648,972–42,649,906 | 95.5 kb | Distal (>10kb) Multiome | 625 | |
| chr22:42,662,035–42,662,743 | 108.3 kb | Distal (>10kb) Multiome | 468 | |
| chr22:42,720,289–42,721,050 | 166.9 kb | Distal (>10kb) Multiome | 297 | |
| chr22:42,800,630–42,801,305 | 247.1 kb | Distal (>10kb) Multiome | 559 |
Genomic view of the SERHL2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.